Overview

Osteoporosis is one of the most common chronic conditions in general practice, and the clinical endpoint that matters is a fragility fracture. Despite this, osteoporosis is underdiagnosed and under-treated in Australia, and many patients who meet PBS criteria for pharmacologic therapy are either on no treatment or on a regimen they struggle to maintain.

This guide takes your practice team through a complete Plan-Do-Study-Act (PDSA) cycle focused on introducing Aclasta (zoledronic acid) infusions as an in-house service. It covers patient selection, pre-infusion pathology, clinical protocol development, consent, nursing checklists and recall logic. The worked example shows how a real practice identified suitable patients, developed and approved a protocol, and embedded the service.

Completing the full cycle can contribute up to 9 Continuing Professional Development (CPD) hours across Educational Activities, Reviewing Performance and Measuring Outcomes categories when submitted as a practice-based or group activity.

What the guide covers

Clinical protocol

Patient selection criteria, pre-infusion pathology thresholds, creatinine clearance calculation, infusion rate, observation schedule and adverse-event pathway. Includes a traffic-light administration criteria table.

Consent and documentation

Informed consent content, Best Practice shortcuts (ACLASTADR), patient-facing advice and consumer medicines information. Covers the ONJ risk conversation at osteoporosis doses.

Nursing checklist and recall

Pre-infusion, in-the-chair and post-infusion nursing checklist. IV access, vital sign observations and adverse reaction protocol. Annual recall setup for ongoing doses.

CPD hours breakdown

Completing the full PDSA cycle can contribute up to 9 CPD hours. The breakdown below shows how hours are allocated across RACGP CPD categories.

Educational Activities (3 hours)

Evidence review, bisphosphonate comparison, ONJ risk at osteoporosis doses, clinical protocol development and team education sessions.

Reviewing Performance (3 hours)

Pre-infusion pathology audit, creatinine clearance and vitamin D status review, outcome tracking across infusions.

Measuring Outcomes (3 hours)

The PDSA cycle itself: planning, implementation, reassessment and documentation of changes embedded in practice workflows.

Key topics

Patient identification and osteoporosis audit

Pre-infusion pathology and safety thresholds

Infusion protocol and nursing procedure

PBS eligibility and billing structure

Consent, ONJ risk and adverse-event management

Revenue opportunity

Unlike cost-avoidance topics, Aclasta infusion is a revenue-generating service that also builds patient retention.

Infusion fee

There is no dedicated MBS item for short-duration infusions in general practice. Practices typically charge a private infusion fee plus a GP supervision fee. Zoledronic acid is PBS-subsidised for qualifying indications.

Patient retention

Patients on annual infusion schedules rarely change practice once the service is established. The service captures patients who would otherwise be sent to a day infusion unit or hospital clinic.

Who should use this guide

Dr Chris Mitchell AM

Rural GP and Rural Generalist with over 35 years of clinical and leadership experience. Past President of the RACGP. Member of the Order of Australia for services to general practice. This guide is based on a PDSA cycle run in his own practices introducing Aclasta infusion as a standard service.

Read the guide

This PDSA guide is free for Australian GP practices.

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